Publications by authors named "L Varinelli"
Article Synopsis
- * The study tested the effects of three natural compounds—quercetin (QER), epigallocatechin gallate (EGG), and fisetin (FIS)—on patient-derived organoids (PDOs) obtained from polyps, assessing their impact on cell growth and apoptosis.
- * Fisetin (FIS) was the most effective compound in inducing cell death in the organoid models, suggesting that diets rich in these compounds could serve as a supplementary strategy to reduce CRC risk in FAP
Background And Objectives: Few preclinical models of pseudomyxoma peritonei (PMP) have been developed, probably due to the tumor's low incidence and its peculiar characteristics of slow growth. Therefore, there is a need to develop more refined PMP models that better reflect its characteristics. The aim of the study is to develop a culture strategy to generate organoid models derived from PMP patient samples.
View Article and Find Full Text PDFEven with systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC), peritoneal metastases (PM) remain a common site of disease progression for colorectal cancer (CRC) and are frequently associated with a poor prognosis. The mass spectrometry (MS) method known as Matrix-Assisted Laser Desorption/Ionization - Time of Flight (MALDI-TOF) is frequently used in medicine to identify structural compounds and biomarkers. It has been demonstrated that lipids are crucial in mediating the aggressive growth of tumors.
View Article and Find Full Text PDFArticle Synopsis
- Peritoneal metastases from colorectal cancer are tough to treat, and while surgeries combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can help, high recurrence rates and a lack of a standard chemotherapy choice remain challenges.
- This study explored the use of patient-derived organoids (PDO) as a model to enhance the effectiveness of HIPEC by testing various chemotherapy drugs on PDOs from twelve patients.
- Results showed significant variability in drug responses, highlighting that certain combinations, like mitomycin-c with cisplatin, were most effective, suggesting that PDOs can help tailor treatments and improve strategies for individual patients with colorectal cancer peritoneal metastases.