Anatomical aspects, technical nuances, and a case series of the resection of the inferior temporal gyrus as a strategy to access the basal surface of the temporal lobe and the lateral incisural space.

Background: Pathologies of the basal surface of the temporal lobe (TL) and the lateral incisural space (IS) commonly present microsurgical challenges. Since the inferior temporal gyrus (ITG) is part of both the lateral and the basal surfaces, it has a close relationship with the basal surface of the TL and lacks major white matter tracts, reducing the risk of eloquence. This study aims to describe the technique of ITG resection, its applications in four surgical cases, and the relevant anatomical aspects.

Repetitive concussions promote microglia-mediated engulfment of presynaptic excitatory input associated with cognitive dysfunction.

Concussions are a current health concern and account for the vast majority of head trauma. While symptoms after a single impact are usually transient, repetitive concussions, as often occur in sports, are responsible for persistent acute and chronic deficits. Here, we used a model of bilateral midline-centered concussions in mice to show that repetitive concussions selectively induce impairments in learning ability compared to single-impact injuries.

Brid., a Bryophyta from Northwest Argentina as a Source of Antioxidants and Antimicrobials.

In recent years, numerous studies have emerged on the biological activities of bryophytes and their potential for therapeutic use. However, mosses appear to be a relatively overlooked group. The objective of this study was to conduct a phytochemical analysis of one hydroalcoholic extract of and to evaluate its potential as an antioxidant and antimicrobial agent.

Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from Using Computational and Bioinformatics Tools.

Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. Inhibiting GST activity can compromise parasite viability. This study reports the successful identification of two selective inhibitors for the mu-class glutathione S-transferase of 25 kDa (Ts25GST) from , named and , using a computationally guided approach.

Regional challenges to optimize the management of patients with severe asthma type 2 inflammation: a Delphi consensus in seven countries.

Severe asthma burdens patients and presents clinical management challenges for healthcare professionals. Biologics are crucial interventions for severe type two (T2) patients with high eosinophil counts. We conducted a Delphi consensus in seven developing or typically underrepresented countries to understand expert agreement on managing severe asthma with type two (T2) inflammation.