Publications by authors named "L V Zueva"
Article Synopsis
- Melanin is a diverse and ancient pigment found in many living organisms, serving protective roles like metal chelation and regulating metal concentrations in cells.
- Melanin can acquire magnetic properties by binding with metals, which may influence how organisms respond to magnetic fields.
- This review focuses on the role of melanin in the vertebrate retina, particularly in migratory birds and fish, and explores its possible connections to magnetic sensing.
Article Synopsis
- Tumor binding plays a crucial role in understanding unbound tumor concentrations, which helps in exploring pharmacokinetics (PK) and pharmacodynamics (PD) in cancer research.
- Research involved evaluating tumor binding across eleven different types of human and mouse tumors, with results showing strong correlations, except for the specific case of mouse melanoma (B16F10).
- Predictive models were created to estimate tumor binding when direct experimental data is lacking, suggesting alternative strategies like using surrogate tissues for initial assessments, specifically recommending OVCAR3 tumors for most cases.
Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of drug metabolism and PK (DMPK) scientists in drug discovery projects. This is typically performed by using in vitro-in vivo extrapolation (IVIVE) based on mechanistic PK models. In recent years, machine learning (ML), with its ability to harness patterns from previous outcomes to predict future events, has gained increased popularity in application to absorption, distribution, metabolism, and excretion (ADME) sciences.
View Article and Find Full Text PDFOne of the known important functions of hair is protection from extensive sunlight. This protection is accomplished in large part due to natural hair pigmentation which is known to reflect the number of melanin granules (melanosomes) in the hair shaft, and melanin variants. Melanin takes in excessive light energy and converts it to heat in a process called absorption; heat is then dissipated into the environment as infrared radiation, thereby protecting the underlying skin.
View Article and Find Full Text PDFArticle Synopsis
- Eye shine research gained momentum with the advent of electronic microscopy in the late 20th century, focusing on the unique microstructures in the tapetum.
- Studies revealed that the tapetum's reflective properties stem from specialized subwavelength arrangements (photonic crystals), which enhance light reflection and eye sensitivity.
- Recent advancements in nano-optics have improved our comprehension of these mechanisms across different vertebrate species, aiding our understanding of their visual systems.