Topology of Ubiquitin Chains in the Chromatosomal Environment of the E3 Ubiquitin Ligase RNF168.

Genome stability is critical for normal functioning of cells, it depends on accuracy of DNA replication, chromosome segregation, and DNA repair. Cellular defense mechanisms against DNA damage are important for preventing cancer development and aging. The E3 ubiquitin ligase RNF168 of the RING superfamily is an essential component of the complex responsible for ubiquitination of the H2A/H2A.

[Evaluation of the effect of prostaglandin analogues and a carbonic anhydrase inhibitor/β-blocker combination on the ocular blood flow in patients with primary open-angle glaucoma].

Purpose: To assess the effect of latanoprost and fixed combination of dorzolamide/timolol on ocular hemodynamics in patients with primary open-angle glaucoma (POAG).

Material And Methods: The study examined 34 patients (56 eyes) aged 51 to 69 years (average - 62.4±9.

[Efficacy and safety of travoprost in patients with primary open-angle glaucoma].

Purpose: To study the hypotensive efficacy and safety of Travapress (0.004% travoprost) in patients with primary open-angle glaucoma (POAG).

Material And Methods: The study included 50 patients (91 eyes) aged 45 to 74 years.