Publications by authors named "L V Wain"
Article Synopsis
- - The study investigates the relationship between diabetes mellitus (DM) and idiopathic pulmonary fibrosis (IPF) using a Mendelian randomisation approach to determine if there is a causal link between the two.
- - Analysis of genetic data showed that neither type 1 diabetes (T1D) nor type 2 diabetes (T2D) appeared to directly cause IPF, nor did other diabetes-related factors like HbA1c or fasting insulin levels.
- - The findings suggest that while DM and IPF often coexist, their relationship may be influenced by common risk factors or complications rather than a direct causal connection.
Background: People hospitalised for coronavirus disease 2019 (COVID-19) have elevated incidence of diabetes. However, it is unclear whether this is due to shared risk factors, confounding or stress hyperglycaemia in response to acute illness.
Methods: We analysed a multicentre prospective cohort study (PHOSP-COVID) of people ≥18 years discharged from NHS hospitals across the United Kingdom following COVID-19.
Background: The clinical course of idiopathic pulmonary fibrosis (IPF) is highly variable and unpredictable, with multiple genetic variants influencing IPF outcomes. Notably, rare pathogenic variants in telomere-related genes are associated with poorer clinical outcomes in these patients. Here we assessed whether rare qualifying variants (QVs) in monogenic adult-onset pulmonary fibrosis (PF) genes are associated with IPF survival.
View Article and Find Full Text PDFBackground: In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) 1 year after discharge.
Methods: Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies (Post-hospitalisation COVID-19 and the International Severe Acute Respiratory and emerging Infection Consortium).