Nucleocytoplasmic distribution of S6K1 depends on the density and motility of MCF-7 cells .

The ribosomal protein S6 kinase 1 (S6K1) is one of the main components of the mTOR/S6K signal transduction pathway, which controls cellular metabolism, autophagy, growth, and proliferation. Overexpression of S6K1 was detected in tumors of different origin including breast cancer, and correlated with the worse disease outcome. In addition, significant accumulation of S6K1 was found in the nuclei of breast carcinoma cells suggesting the implication of kinase nuclear substrates in tumor progression.

[Recurrent endometrial cancer after combined radiation therapy].

Data of a patients are reported who developed recurrence of highly differentiated cancer of the endometrium 20 years after combined. At that time the patient harboured also a borderline mucinous cystadenoma of the ovary with malignization foci. An analysis of the lymphocyte karyotype in the peripheral blood revealed a 14% increase of aberrant cells.

[Early relaparotomies after surgical treatment of cancer of the stomach].

Based on the observation of 40 patients the authors consider that the greatest amount of postoperative complications in patients with gastric cancer make their appearance after reconstructive and palliative gastrectomies and combined operative interventions. Timely relaparotomy allowed saving 37.5% of the patients who had such complications as incompetence of anastomosis sutures, pancreanecrosis, peritonitis, intraabdominal abscesses.