Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects.

Depression associated with poor general medical condition, such as post-stroke (PSD) or post-myocardial infarction (PMID) depression, is characterized by resistance to classical antidepressants. Special treatment strategies should thus be developed for these conditions. Our study aims to investigate the mechanism of action of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine, hydrobromide (L-17), a recently designed thiadiazine derivative with putative neuro- and cardioprotective and antidepressant-like effects, using combined in silico (for prediction of the molecular binding mechanisms), ex vivo (for assessment of the neural excitability using c- immunocytochemistry), and in vivo (for direct examination of the neuronal excitability) methodological approaches.

Three-plane Model to Standardize Laparoscopic Right Hemicolectomy with Extended D3 Lymph Node Dissection.

Aim: The purposes of this study were to create a "three-plane model" for laparoscopic right hemicolectomy and to compare short-term outcomes of anterior medial-to-lateral (aM-to-L) and caudal-to-cranial access by retroperitoneal tunneling (Ca-to-Cr), as described based on the three-plane model.

Methods: A three-plane model was developed to clarify the steps of an operation. Consecutive cases of right colon cancer were operated upon with an aM-to-L approach in the earlier period and then with a Ca-to-Cr approach, and postoperative outcomes were evaluated.

Correction to: Abstracts : 30 European Congress of Pathology.

The author names of abstract PS-03-011 were presented incorrectly in the original publication (Last Name initial and First Name presented). The author names have been corrected. In addition, the authors wish to clarify the Funding details related to their abstract.

Correction to: Abstracts : 30 European Congress of Pathology.

The author names of abstract E-PS-23-005 were presented incorrectly in the original publication (Last Name initial and First Name presented). The author names have been corrected. In addition, the authors wish to clarify the Funding details related to their abstract.