[The role of cAMP phosphodiesterase inhibitors in the pharmacotherapy of the hypoxic syndrome].

The authors studied the pharmacotherapeutic activity of drugs belonging to various pharmacological groups which are inhibitors of cAMP phosphodiesterase in the hypoxic syndrome. The increase in the level of the secondary intermediate of the adenylate cyclase path in transmission of the intracellular signal from the outer surface of the cell to the nucleus, the hypoxia protector cAMP, under the effect of the drugs under study favorably influenced survival and the course of hypoxic hypoxia in overheating. A combination of quercetin bioflavonoid with acetylsalicylic acid demonstrated stronger antihypoxic and thermoprotector properties.

[Antihypoxants: their status and outlook].

The survey deals with the up-to-date information in the literature on the problem of pharmacological correction of pathological changes found in the organism in the hypoxic syndrome. The principal approaches to pharmacotherapy of this pathological condition are pointed out. Information on the up-to-date and effective antihypoxia agents applied in medical practice and those in the stage of development is given.

[Blood serum enzymes in hypoxic syndrome].

Acute hypoxic hypoxia and hyperthermia have been studied for their effect on the activity of rat blood enzymes: lactate dehydrogenase, creatine phosphatase and gamma-glutamine transpeptidase. Simultaneous action of these unfavourable factors on the animals evokes a sharp change in activity of the studied enzymes. Membrane-damaging effect of hypoxia and hyperthermia evidence for the necessity of pharmacocorrection at different stages of development of hypoxic syndrome.

[A biochemiluminescent analysis of the pharmacotherapeutic activity of acetylsalicylic acid in combination with quercetin in a hypoxic syndrome].

The effect of acetylsalicylic acid in combination with quercetin on blood serum biochemiluminescence in the hypoxic syndrome was studied. Possessing marked antioxidant activity, this drug combination prevented changes in the kinetics of blood serum luminescence in all periods of the investigation.