Publications by authors named "L V Sarkisian"
Article Synopsis
- Bystander defibrillation boosts survival rates and good neurological outcomes for out-of-hospital cardiac arrest (OHCA) cases, and understanding lay responders' impact is important.
- In a study involving 715 OHCA patients from two Danish hospitals, 125 cases had lay responders arrive before EMS, with 81 patients defibrillated by them compared to 69 by bystanders and 565 by EMS staff.
- Results showed that 3-month survival with good neurological outcomes was at 81% for bystander cases compared to 65% for lay responders, indicating that bystander intervention is more effective in improving patient outcomes.
Treatment effects of blood pressure targets and hemodynamics according to initial blood lactate levels in comatose out-of-hospital cardiac arrest patients - A sub study of the BOX trial.
Resuscitation
January 2024
Background: Out-of-hospital cardiac arrest (OHCA) survivors remaining comatose are often circulatory unstable with high mortality in the first days following resuscitation. Elevated lactate will reflect the severity and duration of hypoperfusion in cardiac arrest. Further, the severity of hypoperfusion could modify the effect on survival of different mean arterial blood pressure (MAP) targets.
View Article and Find Full Text PDFAim: The aim of this retrospective observational study was to determine how response intervals correlated to the experience of the community first responders (CFRs) using data collected from the Danish Island of Langeland via a global positioning system (GPS)-based system.
Methods: All medical emergency calls involving CFRs in the time period from 21st of April 2012 to 31st of December 2017 were included. Each emergency call activated 3 CFRs.
Article Synopsis
- Guidelines recommend active fever prevention for 72 hours after cardiac arrest, but evidence from clinical trials on its effectiveness is lacking.
- In a study of comatose patients resuscitated after cardiac arrest, researchers compared temperature control interventions for either 36 or 72 hours.
- The results showed no significant differences in mortality or disability rates between the two groups at 90 days, indicating that fever prevention for 36 hours could be as effective as 72 hours.
Background: The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown.
Methods: In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with out-of-hospital cardiac arrest in a 1:1 ratio to either a restrictive oxygen target of a partial pressure of arterial oxygen (Pao) of 9 to 10 kPa (68 to 75 mm Hg) or a liberal oxygen target of a Pao of 13 to 14 kPa (98 to 105 mm Hg); patients were also assigned to one of two blood-pressure targets (reported separately). The primary outcome was a composite of death from any cause or hospital discharge with severe disability or coma (Cerebral Performance Category [CPC] of 3 or 4; categories range from 1 to 5, with higher values indicating more severe disability), whichever occurred first within 90 days after randomization.