[Trephine biopsy of the bone marrow in patients with hairy cell leukemia].

The bone marrow histological picture was studied in 13 patients with hairy-cell leukemia (HCL) who were followed up at the Hematological Centre in the Latvian SSR. The diagnosis was made or proved in all the cases, among them in 9 patients - on the basis of the proliferation type of leukemia cells in the bone marrow trephine biopsy that is characteristic of HCL. The analysis of the clinical and morphological features of the disease has permitted the authors to distinguish specific types of HCL: 1) splenic and bone-marrow variants predominantly were diagnosed clinically, 2) typical and atypical variants resembling malignant lymphoma or chronic lymphoid leukemia were diagnosed histomorphologically.

[Familial myeloproliferative syndrome (study of 4 families and review of the literature)].

The authors describe 4 families whose members showed myeloproliferative diseases. In one of the families, polycythemia vera (PV) was seen in twin brother and sister, in the other one, chronic myeloleukemia (CML) afflicted both daughter and mother, and in the two remaining families PV and CML afflicted two brothers and mother and daughter, respectively. It was established that neutrophil phosphatase activity was lowered not only in the afflicted brother but also in healthy members of the third family.