[Evoked retinal and cortical potentials in children with advanced and resistant retinoblastoma after neoadjuvant polychemotherapy and superselective intra-arterial chemotherapy].

Electrophysiological examinations (in accordance with the ISCEV Standards and original protocols) were performed after neoadjuvant chemotherapy or before and after superselective intra-arterial chemotherapy (SIACT) in 18 children aged 1-3 years with either newly diagnosed advanced retinoblastoma (8 eyes) or resistant retinoblastoma (14 eyes). The most considerable decrease in amplitude was demonstrated by the cone response b-wave, photopic 24 Hz flicker electroretinogram (ERG), photopic negative response, and the P1-component of multifocal ERG, indicating a significant dysfunction of bipolar and ganglion cells, more pronounced in the macular zone. After the SIACT, central retinal functions improved.

[Method of surgical chemotherapy on organism automedia during surgical procedures for breast and colon cancer].

Method of surgical chemotherapy on organism automedia during surgical procedures for breast and colon malignant tumors has been developed. The method consists in intravenous autohemochemotherapy and local autoplasmochemotherapy (into residuary mammary tissue or regional arterial mesenteric vessel).

[Polychemotherapy-induced changes in the antioxidant state of blood in patients with inoperable cancer of the stomach].

Changes in antioxidant characteristics of blood in patients with inoperable tumors of the stomach were followed before and after combination polychemotherapy which comprised intraperitoneal and endolymphatic injection of drugs. General strengthening therapy was given prior to treatment. It was found that enzymatic activity as a component of antioxidant defenses offered by lymphocytes is low in such patients which adversely affects the structural and functional integrity of lymphocyte membranes.

[Superoxide-neutralizing activity of blood serum in cases of primary multiple malignant tumors].

An earlier investigation of the superoxide-neutralizing activity of blood serum sampled from patients with primary multiple malignancies detected for the first time RF-proteins as well as their tropism to the target organ from which tumor was removed 2-30 years before. A possible explanation may be that a general reaction of the body presented itself. The present study has led to a conclusion that, in cases of polyneoplasia, successful complex treatment of primary malignancy, carried out however for back, might be masked by RF-protein function: the latter "indicates" the presence of foci of malignancy which are not there any longer.