Publications by authors named "L V Mikhaleva"
Unlabelled: Currently, chronic salpingo-oophoritis (CS) is still an urgent problem in the statistics of diseases of the female genital organs. In 35% of women, its course leads to disorder of the fallopian tubes patency and infertility. An additional indirect mechanism of infertility can be the morpho-functional failure of the endometrium.
View Article and Find Full Text PDFObjective: To study the features of protein expression of gene in primary breast cancer (BC) and to identify its relationship with regional metastasis.
Material And Methods: The study included 358 cases of primary BC stages I-III without neoadjuvant chemotherapy with an assessment of a number of clinical, morphological and immunohistochemical parameters of the tumor, including NDRG1 protein expression status and its expression level.
Results: In two study groups with and without metastatic lymph node involvement, a statistically significant relationship was found between NDRG1 expression and histological type of BC, tumor grade, estrogen receptors expression, progesterone receptors expression, HER2 status and index Ki-67 (tumor cell proliferative activity).
Article Synopsis
- The study investigates how dark deprivation influences liver health and circadian rhythms when exposed to carbon tetrachloride (CCl), a known hepatotoxic agent.
- While much is known about CCl's effects on the liver, research on its impact within the context of circadian rhythms is limited, and many studies focus on isolated periods rather than the overall rhythm.
- Findings suggest that dark deprivation leads to more severe structural and functional liver changes due to reduced melatonin levels, indicating the need for further research on the role of melatonin in these processes.
Article Synopsis
- The literature review highlights the significance of cellular adhesion proteins (CAP) in heart health, focusing on their role in maintaining connections between heart muscle cells (cardiomyocytes) and facilitating electrical impulse transmission.
- An imbalance in these proteins, primarily due to hereditary factors, leads to damage in intercalated discs, resulting in impaired impulse transmission and increasing the risk of cardiac arrhythmias, such as atrial and ventricular fibrillation.
- Additionally, endothelial dysfunction contributes to atrial fibrillation by disrupting the CAP in the endocardium and blood vessels, further emphasizing the interconnectedness of cellular adhesion and heart disorders.
Article Synopsis
- Cardiac involvement is crucial in determining the prognosis for systemic amyloidosis patients, with a study analyzing 98 patients focusing on which amyloid types impact the heart most significantly.
- The study categorized patients into two groups: those diagnosed via endomyocardial biopsies (EMBs) and those diagnosed post-mortem through autopsy, revealing varying types of amyloidosis in each group.
- Findings indicated a notable underdiagnosis of ATTR amyloidosis, particularly in elderly patients, and highlighted that AL kappa amyloidosis leads to more severe amyloid deposits and worse outcomes.