Predictive markers of response to immune checkpoint inhibitor rechallenge in metastatic non-small cell lung cancer.

Aim: The present study aims to evaluate the efficacy of rechallenge with immune checkpoint inhibitors (ICIs) compared to chemotherapy and the predictive role of clinical parameters in non-small cell lung cancer (NSCLC) patients who were rechallenged.

Methods: The study included 113 metastatic NSCLC patients who had initially responded to ICIs and platinum-based chemotherapy, either in combination in the first line or sequentially in the first and second line, but later experienced disease progression. Of those patients, 52 later received ICI rechallenge and 61 were exposed to chemotherapy.

[Childhood disability due to mental disorders in the Arkhangelsk region: structural and dynamic trends].

Objective: To examine the structural-dynamic trends in disability in children aged 0-14 and 15-17 in the Arkhangelsk region (AO) over the period 2010-2020.

Material And Methods: The age-standardized rates of primary and total disability calculated on the basis of the official statistical data presented in the form No.19 «Statistics on Disabled Children» for 2010-2020 in AO excluding Nenets autonomous district.

[The experience of SERVQUAL technique application in measuring satisfaction of patients with medical services quality].

The implementation of system of quality control conforming to requirements of interstate ISO 9001 standards in in the medical organization, the important role is assigned to indicator of satisfaction of patients with quality of medical care as a feedback channel. The study purpose was to investigate satisfaction of patients with quality of medical services in medical organization rendering hospital medical care on the basis of SERVQUAL technique. The analysis of results of survey of 339 patients treated in the twenty-four-hour department of municipal hospital demonstrated rather high rating of perception of quality of rendered medical services that made up to 4.

[The disability due to industrial injuries and occupational diseases in the Arkhangelsk Oblast].

The article presents analysis of primary disability in the Northern Region as compared with The Russian Federation. The dynamics and structure of disability due to occupational injuries and diseases is presented. In 2008-2018, in the Arkhangelsk Oblast the level of disability for the analyzed group of causes decreased up to 9.