Publications by authors named "L V Mendelsohn"
African American (AA) women are disproportionally affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) contributing to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair Natural Killer cells (NKs). As potential common underlying mechanisms are largely unknown, we sought to investigate common signaling pathways involved in NK dysfunction related to obesity and hyperlipidemia in AA women from under-resourced neighborhoods.
View Article and Find Full Text PDFPurpose: This phase II study evaluated the efficacy and tolerability of onvansertib, a polo-like kinase 1 (PLK1) inhibitor, in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) + bevacizumab for the second-line treatment of -mutant metastatic colorectal cancer (mCRC).
Patients And Methods: This multicenter, open-label, single-arm study enrolled patients with -mutated mCRC previously treated with oxaliplatin and fluorouracil with or without bevacizumab. Patients received onvansertib (15 mg/m once daily on days 1-5 and 15-19 of a 28-day cycle) and FOLFIRI + bevacizumab (days 1 and 15).
Article Synopsis
- The text discusses a method for catalyzing asymmetric hydrogenation of indazole-containing enamides, specifically for synthesizing zavegepant, a new migraine treatment.
- It highlights the effectiveness of both neutral bis(phosphine)cobalt(II) and cationic bis(phosphine)cobalt(I) complexes as precatalysts, achieving high yields and selectivity in the hydrogenation reactions.
- Additionally, it mentions the successful hydrogenation of a specific enamide on a large scale (20 grams), showing practical application in the synthesis process.