Publications by authors named "L V Mekheda"
[Intrathecal chemotherapy for leptomeningeal metastases in patients with breast cancer].
Zh Vopr Neirokhir Im N N Burdenko
June 2024
Unlabelled: Leptomeningeal metastases are lesions of brain and/or spinal cord sheaths by tumor cells. They occur in 5% of patients with solid tumors, although autopsies reveal these lesions much more often (10-20% of cases). Leptomengeal metastases are an unfavorable prognostic factor.
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- Soft tissue sarcomas (STS) are complex cancers with over 100 subtypes, making personalized therapies challenging and commonly treated with specific chemotherapy combinations like Doxorubicin and Ifosfamide.
- Chemotherapy is only effective for less than half of the patients, leading to rapid drug resistance, particularly in undifferentiated pleomorphic and synovial sarcomas.
- The study identified genetic alterations in apoptotic signaling pathways linked to chemoresistance, revealing that 27% of tumors had these genetic changes, which significantly impacted the effectiveness of Doxorubicin, informing future treatment strategies.
Analysis of Multiple Drug Resistance Mechanism in Different Types of Soft Tissue Sarcomas: Assessment of the Expression of ABC-Transporters, MVP, YB-1, and Analysis of Their Correlation with Chemosensitivity of Cancer Cells.
Natalia I Moiseeva Lidia A Laletina Timur I Fetisov Leyla F Makhmudova Angelika E Manikaylo Larisa V Mekheda
Int J Mol Sci
March 2022
Chemotherapy of soft tissue sarcomas (STS) is restricted by low chemosensitivity and multiple drug resistance (MDR). The purpose of our study was the analysis of MDR mechanism in different types of STS. We assessed the expression of ABC-transporters, , , and analyzed their correlation with chemosensitivity of cancer cells.
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