[Myocardial infarction: peculiarities of lipid metabolism, oxidative and antioxidative potential].

Characteristics of lipid metabolism, lipid peroxidation products (LPP), and antioxidative potential were determined in patients with acute myocardial infarction. Minor variations of serum total cholesterol, LDL, and triglycerids were detected in patients with small-focal MI. After completion of therapy cholesterol dropped only in patients with transmural infarction.

[Oxidative stress in myocardial infarction and the efficiency of its correction with the drug Trimetazidine].

The purpose of the study was to assess efficiency of the use of trimetazidine (Preductal MR) in therapy of acute myocardial infarction (MI) on the grounds of examination of oxidative potential of erythrocytes and blood serum, antioxidative enzyme activity. Group of patients with acute small-focal, large-focal and transmural myocardial infarction, who received traditional therapy and in addition cytoprotective drug trimetazidine, was examined. Primary and secondary products of lipid peroxidation (LP), antioxidative enzymes were analyzed on 1st and 21st day after the beginning of anginous attack.

[Characteristic changes of skin and its accessories in type 2 diabetes mellitus].

The different changes are seen on skin and it's accessories in Diabetes Mellitus, some of which represent the prognostic indicator of complicated diabetes and some directly contribute in development of them. Numerous problems concerned with the diabetic foot could be avoided due to early detection and treatment of these changes. The objective data on foot examination of 195 patient with Type 2 Diabetes Mellitus were analyzed considering the grade of severity of Diabetic Peripheral Neuropathy (DPN).

[Spinal fluid in central nervous system diseases].

Erythrocytes, extracellular hemoglobin and bilirubin level, a quantity of medium mass molecules and catalase activity were determined in the spinal fluid of 32 patient with closed craniocerebral injury of the various degree 24 hours after accident. The extracellular hemoglobin and the bilirubin level were shown to appear in cases with cerebral contusion in association with bleeding only, failed to reflect state severity degree at the early stage after injury. As the number of medium mass molecules increases significantly only in the patients with severe contusions, this index can be used for description of the severity of the process and for evaluation of the deterioration of the clearance of proteolytic products resulting in endogenous intoxication of the central nervous system.