[CERULOPLASMIN CORRECTION OF DYSLIPIDEMIA CAUSED BY CHRONIC PHYSICAL LOAD IN EXPERIMENT AT SUBMAXIMAL POWER.].

Chronic submaximal physical load of aerobic-anaerobic charater leads to pro-atherogenic dyslipidemia, as manifested by increased levels of triglycerides, total cholesterol, and very-low-density lipoproteins. Ceruloplasmin (total dose 60 mg/kg body weight, triple intraperitoneal introduction on the 1st, 3rd, and 5th day of experiment) produced a partial correction of dyslipidemia, manifested by restoration of the normal levels of triglycerides, total cholesterol, and lipoproteins of very low, low, and high density. At the same time, ceruloplasmin administration did not influence the level of phospholipids.

Effect of ceruloplasmin on the number and resistance of erythrocytes during acute physical exercise.

Acute physical exercise was followed by a decrease in the osmotic resistance of erythrocytes, shortening of the time-to-onset of erythrocyte hemolysis, and increase in the sorption capacity of the cell membrane. Administration of ceruloplasmin 24 h before physical exercise normalizes membrane resistance in red blood cells.

Effects of alpha1-acid glycoprotein on hemostasis in experimental septic peritonitis.

Pathogenesis of hemostasis disorders in septic peritonitis and the possibility of their correction with acute phase protein (alpha1-acid glycoprotein; two doses of 150 mg/kg) were experimentally studied on outbred albino rats. Platelets count in the peripheral blood and their adhesion to endothelium did not change during peritonitis, while aggregation activity increased due to increased rate and shorter time of aggregation, which was associated with the development of hypercoagulation involving the intrinsic and common coagulation pathways and reduction of antithrombin activity. alpha1-Acid glycoprotein increased platelet count above the normal level, normalized aggregation rate, some blood clotting parameters, and antithrombin activity.

[Influence of alpha-1-acid glycoprotein on blood rheology].

Hemorheologic effects of alpha-1-acid glycoprotein (AGP) were studied in experiment on 76 noninbred white male rats. AGP was administered i.p.

Ceruloplasmin prevents hemostatic disorders during experimental hyperammonemia.

Experimental hyperammonemia in rats was accompanied by hemostatic disorders manifesting in coagulopathy (activation of the intrinsic pathway of blood coagulation) and suppression of platelet function. Ceruloplasmin in a total dose of 60 mg/kg effectively normalized coagulation hemostasis and functional activity of platelets by improving secretory processes in platelets and increasing aggregation rate.