Publications by authors named "L V Kalia"

Background And Objectives: Disease-modifying treatments (DMTs) are a major unmet need in Parkinson disease (PD). To date, trials investigating DMT candidates in PD most often used a randomized controlled trial (RCT) design. Unfortunately, RCTs to date have not led to a breakthrough, in part because of the large sample sizes and length of follow-up required.

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  • * Recently, there have been great breakthroughs for MS, with new medications being approved, but people with PD still have not gotten new treatments and only have old ones that don't work as well.
  • * Experts from around the world gathered in Toronto to discuss how to improve treatment for PD by learning from what worked for MS, focusing on things like better clinical trials and understanding the diseases better.
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  • The Canadian Open Parkinson Network (C-OPN) aims to enhance collaboration between study participants, clinicians, and researchers to boost Parkinson's disease research across ten universities and research centers in Canada.
  • The C-OPN database collects a variety of data, including demographic information, treatment approaches, and biological samples, which are accessible for multi-center studies via web-based systems like REDCap.
  • By November 2023, the C-OPN had enrolled 1,505 participants, with a focus on environmental and symptom analysis, serving as a platform for innovative research and collaboration among scientists in Canada.
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