Publications by authors named "L V Gould"
Background: The Wound Care Collaborative Community (WCCC) aims to assess current usable real-world data (RWD) sources to determine which real-world databases (DBs) are suitable and usable for studying the natural history of chronic wounds. Randomized controlled trials (RCTs) do not fully reflect the complexity of patients with chronic wounds. Using RWD, establishment of a scientifically grounded "road map" for RCTs is needed to better navigate the real-world complexity of the patients with chronic wounds.
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- Preclinical studies are crucial for developing therapies for wound healing disorders, offering safety screening and insights through in vivo approaches.
- Current animal testing guidelines are inadequate due to the complexity of wound healing processes, leading to inconsistencies in study interpretation.
- The newly established Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines aim to standardize the reporting of experimental conditions in preclinical wound healing studies to improve transparency and support future clinical trials.
Sudden unexplained death in childhood (SUDC) is death of a child ≥ 12 months old that is unexplained after autopsy and detailed analyses. Among SUDC cases, ~ 30% have febrile seizure (FS) history, versus 2-5% in the general population. SUDC cases share features with sudden unexpected death in epilepsy (SUDEP) and sudden infant death syndrome (SIDS), in which brainstem autonomic dysfunction is implicated.
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