Publications by authors named "L V Galindo"
A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.
Front Oncol
December 2024
Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.
View Article and Find Full Text PDFEukaryotes evolved from prokaryotic predecessors in the early Proterozoic and radiated from their already complex last common ancestor, diversifying into several supergroups with unresolved deep evolutionary connections. They evolved extremely diverse lifestyles, playing crucial roles in the carbon cycle. Heterotrophic flagellates are arguably the most diverse eukaryotes and often occupy basal positions in phylogenetic trees.
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- The study explores challenges in lung cancer biomarker testing due to tissue inadequacy and operational issues, implementing a tailored molecular testing approach in Brazil.
- From 1,272 lung cancer samples analyzed, a significant percentage were ineligible for testing due to insufficient tissue quality or quantity, with specific mutations and alterations being most commonly observed.
- Results suggest that while non-NGS tests provided some diagnostic information, a substantial portion of patients could only access reduced molecular testing coverage, impacting the detection of actionable cancer drivers.
Background: Traditionally, the administration of large volumes of fresh frozen plasma (FFP) was common during liver transplant surgery, with no improvement in the results in terms of bleeding and blood-saving. Moreover, this hydric overload caused by FFP may be harmful, leading to an increase in hospital stays and patient morbidity.
Methods: The objective is to assess the morbidity associated to the use of FFP in the intraoperative period of patients undergoing orthotopic liver transplantation.
Article Synopsis
- Vascular grafts typically made from synthetic materials face issues like thrombosis and intimal hyperplasia, especially in small diameters, prompting research into alternative options such as decellularized plant scaffolds.* -
- The study developed a novel bioreactor to precondition small-diameter vascular grafts made from decellularized leatherleaf viburnum, simulating physiological conditions to enhance cell density and reduce thrombus formation.* -
- Results showed that bioreactor conditioning improved the grafts’ endothelial cell density and suture retention while maintaining cell viability, indicating the potential of these plant-based grafts for vascular repair with lower risk of blood clots.*