Publications by authors named "L V Fedorova"
PD-1 inhibitors have shown unconventional response patterns in classic Hodgkin lymphoma (cHL). These include the phenomenon of pseudoprogression, highlighting the need for specialized response criteria such as the LyRIC, which stringened definitions for disease progression with introduction of indeterminate response category. Despite their potential utility, these provisional criteria are currently underutilized and require further refinement through clinical practice data collection.
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- The study focuses on the role of mobile genetic elements in spreading biocide and antibiotic resistance among bacteria, specifically the qacEΔ1 gene that provides resistance to quaternary ammonium compounds (QACs).
- Researchers developed a TaqMan real-time PCR assay to detect the qacEΔ1 gene in Gram-negative bacteria, which can accurately identify even low quantities (as few as 80 copies) without false results.
- This assay serves as a rapid, sensitive, and specific method for monitoring QAC resistance, tracking the spread of class 1 integrons, and predicting multidrug-resistant (MDR) traits in Gram-negative bacteria.
Thousands of prolonged sequences of human ultra-conserved non-coding elements (UCNEs) share only one common feature: peculiarities in the unique composition of their dinucleotides. Here we investigate whether the numerous weak signals emanating from these dinucleotide arrangements can be used for computational identification of UCNEs within the human genome. For this purpose, we analyzed 4272 UCNE sequences, encompassing 1 393 448 nucleotides, alongside equally sized control samples of randomly selected human genomic sequences.
View Article and Find Full Text PDFAmong different inorganic and organic polarizer elements, thin-film light polarizers occupy a special place because of their flexibility, ease of integration into any optoelectronic circuit, and good functioning in the visible and near-infrared spectral range and can compete with Glan and Nicolas volumetric prisms. This paper presents the results of a study on how carbon-based nanoparticles influence on the basic properties of a well-known PVA-based polymer matrix, using which it is possible to obtain good transparency for parallel light components. An accent is made on graphene oxide nanoparticles, which are used as PVA sensitizers.
View Article and Find Full Text PDFEvent rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).
BMC Med
February 2024
Article Synopsis
- - The study aimed to explore long-term health outcomes in children and young people post-COVID-19, particularly focusing on post-COVID-19 condition (PCC) and incomplete recovery, comparing these outcomes with those from other non-SARS-CoV-2 infections.
- - Conducted in Moscow, researchers followed two cohorts of pediatric patients with confirmed COVID-19 from two different time periods (Wuhan and Omicron variants) and compared them to a reference group of those with other infections but negative for SARS-CoV-2.
- - Findings revealed that the incidence of PCC was significantly higher in the Wuhan variant group compared to the reference group, while the Omicron variant showed no significant difference in PCC outcomes when compared to the