Publications by authors named "L V Deshpande"
Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.
Am J Physiol Lung Cell Mol Physiol
January 2025
Neutrophil elastase (NE), elevated in the cystic fibrosis (CF) airway, causes macrophage phagocytic failure. We previously reported that NE increases the release of protease calcium ion-dependent papain-like cysteine protease-2 (Calpain-2) in macrophages. We hypothesized that NE mediates macrophage failure through activation of Calpains.
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- * A significant 82.1% of the isolates showed resistance to fluconazole, while 17.9% were resistant to amphotericin B; however, rezafungin remained effective against 96.2% of the isolates.
- * The majority of isolates belonged to South Asian Clade I, with high fluconazole resistance, alongside notable mutations detected in resistance-related genes, highlighting
isolates from the United States (n = 1038; 2019-2021) were susceptible to omadacycline (99.8%), levofloxacin (99.7%), and ceftriaxone (98.
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- Pneumococcal conjugate vaccines (PCVs), especially newer versions like PCV20, have a significant potential to reduce ear infections (otitis media) in young children by covering more serotypes of bacteria.
- A study examined 199 isolates from the middle ear fluid of U.S. children, finding that 56.8% were from kids under age 2 and identifying key serotypes that contribute to infections, with PCV20 covering 54.8% of these.
- The research indicated a concerning level of antimicrobial resistance, with 45.2% of isolates being non-susceptible to penicillin, suggesting that expanding the coverage of vaccines could help combat both susceptible and resistant types of pneumoc
Hepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic metabolism is associated with longevity. However, few studies have examined the genome-wide impact of epigenetic aging on these processes. We used reduced representation bisulfite sequencing (RRBS) to map DNA methylation changes in liver DNA from mice ages 4 and 24 months.
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