Clustogenesis level in children with gastroduodenal diseases.

The mean count of cells with chromosome aberrations increased in a 72-h culture of peripheral blood lymphocytes of children with Helicobacter pylori-associated gastroduodenal diseases. After eradication therapy, intensification of clastogenesis was observed in the majority of children. Addition of vetoron to the treatment protocols reduced manifestations of clastogenesis.

[Modification with ascorbic acid of the level of spontaneous and induced chromosome aberrations and sister chromatid exchanges in lymphocytes of workers in contact with molybdenum salts].

Five workers of molybdenum gilding at the metallurgical works were observed prior to and after administration of ascorbic acid. Tests for chromosomal aberrations (CA) and sister chromatid exchanges (SCE) were used as the criteria for estimation. Individual sensitivity to the chemicals was revealed in the workers.

[Genotoxic effects of molybdenum and its derivatives in an experiment on Drosophila and mammals].

As a result of research it is established that molybdenum shows the most pronounced genetic activity at the early stages of spermatogenesis. Genetic effects of molybdenum and its modification by vitamin S are registered in the test of dominant lethal mutations. The cytogenetic activity of molybdenum, the molybdenic candle-end and its modification by antibacterial preparation have been revealed in the cells of mammalian marrow.

[The genetic action of ammonium molybdate and cadmium chloride and iodide].

Ammonium molybdate cadmium iodide and cadmium chloride have been studied in test for their genotoxic effect on induction of DNA-cellular bonding, extrasynthesis of DNA in spermatozoa of mice as well as in test to estimate a fertility criterion of Drosophila males. Ammonium molybdate, cadmium iodide and cadmium chloride are stated to be able to induce injuries of native DNA in test on induction of DNA-cellular bonding and DNA-sex cells of mice and Drosophila melanogaster in dominant-lethal test and in experiments on estimation of a fertility coefficient of Drosophila males, respectively.

[The detection of high-risk groups among workers in contact with heavy metals based on an analysis of chromosome aberrations and sister chromatid exchanges].

Heavy metal salts, the workers from molybdenum, tungsten and cobalt plants to make in contact with, reveal their mutagenic activity. Individual sensitivity to heavy metal salts has been analyzed through the example of molybdenum. Chromosome aberrations and sister chromatid exchanges have been studied for the regularities of their formation in lymphocytes of workers depending on the length of service.