[Biological properties of live and inactivated influenza vaccines under experimental conditions].

Biological properties of influenza vaccines were studied on experimental animals inoculated intraperitoneally with regard to the vaccine effect on peritoneal exudate cells. The development of neutrophilia and inhibition of acid phosphatase activity in macrophages within the first 24 hours after intraperitoneal inoculation of influenza viruses or influenza vaccines were used for determination of the toxic effect of the inoculum. The values of subsequent later activation of acid phosphatase in macrophages allowed the immunogenic properties of the vaccines under study to be evaluated.

[State of cellular immunity and phagocytes in guinea pigs infected with Mycoplasma pneumoniae].

The work presents the results of the study of experimental Mycoplasma pneumoniae infection in guinea-pigs. A considerable increase in the engulfment of mycoplasmas and blood leukocytes was found to occur on days 14-28 after the infection. The correlation between the degree of the engulfment of mycoplasmas by macrophages and the activity of lymphocytes in the reaction of blast-cell transformation with phytohemagglutinin and Mycoplasma antigen was observed.

[The course of the protective cellular reactions to the intraperitoneal administration of different influenza virus strains in newborn mice].

The features of response of the macrophagal system in relation to the development of inflammatory reaction caused by PMN-leukocytes in response to intraperitoneal inoculation of newborn white mice with various influenza virus strains of different degrees of attenuation were studied. With the A2/Frunze/76 virus highly toxic for mice the protection was exerted mostly by neutrophils whereas the participation of macrophages in host resistance under these conditions was comparatively small. With the decline of inflammatory PMN-reaction upon intraperitoneal inoculation of A2/Leningrad/337/76 virus the number and functional activity of macrophages participating in the reaction increased.

[Toxic action of influenza virus on lymphoid-macrophagal reactions in guinea pigs].

Influenza viruses with different degrees of virulence for the human being produced various reactions of the lymphoid-macrophagal elements in the peritoneal exudate of guinea pigs inoculated intraperitoneally. The higher the virulence of the strain for the human being -- the deeper the inhibition of the lymphoid and macrophagal cells of guinea pigs. Low virulent strains of influenza virus induced a considerable functional activity of macrophages, but were devoid of the lympholytic activity.