Salivary Transmembrane Mucins of the MUC1 Family (CA 15-3, CA 27.29, MCA) in Breast Cancer: The Effect of Human Epidermal Growth Factor Receptor 2 (HER2).

The MUC1 family of transmembrane glycoproteins (CA 15-3, CA 27.29, MCA) is aberrantly expressed among patients with breast cancer. : to measure the level of degradation products of MUC1, including CA 15-3, CA 27.

Salivary Metabolites in Breast Cancer and Fibroadenomas: Focus on Menopausal Status and BMI.

Unlabelled: This study of the features of the biochemical composition of biological fluids in patients with breast cancer, including saliva, allows us to identify some indicators as metabolic predictors of the presence of the disease.

Objectives: to study the influence of the menopause factor and body mass index (BMI) on the biochemical composition of saliva and to evaluate the applicability of metabolic markers of saliva for the diagnosis of breast cancer.

Methods: The case-control study involved 1438 people (breast cancer, = 543; fibroadenomas, = 597; control, = 298).

Tissue Interactions in Dense Tissues of the Orofacial Region in Patients with Connective Tissue Dysplasia.

Aims: This study aimed to investigate the rate and quality of maturation of the mineral component of impacted teeth 38 and 48 and a fragment of the human lower jaw with connective tissue dysplasia (CTD) in different periods of postnatal ontogenesis.

Methods And Material: The study involved 102 males (76 with CTD and 26 without CTD), divided into age groups: 31-40, 41-50 and 51-60 years. For medical reasons, teeth 38 and 48 were removed from each patient, as well as a fragment of the alveolar part of the lower jaw in the projection of teeth 38 and 48 measuring 0.

Salivary Biomarkers in Breast Cancer: From Salivaomics to Salivaoncoomics.

Saliva is a promising biological fluid for the diagnosis and monitoring of diseases, including breast cancer. To study the composition of saliva, a complex of "omics" technologies is used: genomics, transcriptomics, proteomics, metabolomics and microbiomics. In this review, we systematized all known "omics" in their application to saliva analysis in breast cancer in order to understand how complete the picture is provided by the combination of different areas of research and to identify missing links.

The Role of Salivary Vascular Endothelial Growth Factor A, Cytokines, and Amino Acids in Immunomodulation and Angiogenesis in Breast Cancer.

In this work, we focused on the analysis of VEGF content in saliva and its relationship with pro-inflammatory cytokines and amino acids involved in immunomodulation and angiogenesis in breast cancer. The study included 230 breast cancer patients, 92 patients with benign breast disease, and 59 healthy controls. Before treatment, saliva samples were obtained from all participants, and the content of VEGF and cytokines in saliva was determined by an enzyme-linked immunosorbent assay, as well as the content of amino acids by high-performance liquid chromatography.