[The phenotypic and functional characteristics of cells of inherent and adaptive immunity of newborns of various gestation age.].

During last years, a large number of studies related to investigation of development of immune system at early stages of ontogenesis are directed to expansion of concepts of mechanisms of inherent and adaptive immunity in premature newborns. However, discrepancy in publication data and absence of accurate conceptions about condition of immune system in children of various gestation age determine actuality of further investigation of this problem. The study was carried out to establish characteristics of phenotypic and functional characteristics of cells of inherent and adaptive immunity.

Risk factors vary early preterm birth and perinatal complications after assisted reproductive technology.

We conducted a study of markers of endothelial dysfunction and angiogenesis regulation, as well as the identification of the main lymphocyte populations, activated CD3  CD95-cells and cytokine-producing CD4  IFN-γ-, CD4  IL-4-lymphocytes in the 1st trimester of gestation in women with ART-induced pregnancy and spontaneous pregnancy. We used the same indicators to assess the immune status of ELBW infants at birth and at the post-conceptual age of 38-40 weeks. It was determined that the risk factors of very early preterm delivery are: threatened miscarriage, chronic placental insufficiency, endothelial dysfunction, increased spontaneous production of intracellular cytokines.