Publications by authors named "L Ungureanu"
In the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations, xerosis, scrotal erythema, and subungual splinter hemorrhages.
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- * It reviews pharmacological treatments for common sleep issues like REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), insomnia, and restless legs syndrome (RLS), emphasizing the use of melatonin, clonazepam, modafinil, and caffeine.
- * The article suggests that optimizing dopaminergic treatments at night and maintaining good sleep hygiene can improve sleep quality, but more evidence is needed to widely recommend some of the therapies mentioned.
Melanoma is the most severe form of skin cancer with an incidence that is increasing all over the world. Melanoma cells derive from normal melanocytes and share different melanocyte-specific antigens, the same antigens against which an immune reaction develops in vitiligo, a skin disease characterized by autoimmune-mediated melanocyte destruction. The purpose of this review is to present the autoimmune-mediated melanocyte destruction associated with melanoma development, progression and treatment.
View Article and Find Full Text PDFBasal cell carcinoma (BCC) is the most frequent of all cancers, with an increasing incidence. The first line therapy is surgical excision, but topical therapies can be used in low-risk superficial BCCs, while the more advanced, unresectable, or metastatic BCCs benefit from systemic therapies with hedgehog inhibitors and immunotherapy. The purpose of this review is to highlight local and systemic immunotherapies and their efficacy in the management of BCCs.
View Article and Find Full Text PDFPRAME Immunohistochemistry in Thin Melanomas Compared to Melanocytic Nevi.
Diagnostics (Basel)
September 2024
Article Synopsis
- - PRAME immunohistochemistry is effective for differentiating between malignant thin melanomas and benign melanocytic nevi, with specific staining patterns observed in each.
- - In the study, 26% of melanomas exhibited strong PRAME staining (4+), while none of the nevi reached this level, indicating a clear distinction in PRAME expression.
- - Lowering the positivity threshold for PRAME staining can enhance sensitivity for detecting thin melanomas without significantly compromising specificity, suggesting a more nuanced approach may be beneficial.