Zebrafish facilitates drug screening: potential of 3-deoxy-andrographoside from Chuanxinlian ) as an anti-inflammatory agent.

Objective: To systematically evaluate the anti-inflammatory potential of diterpene lactones from Chuanxinlian () (AP).

Methods: We firstly adopted zebrafish, a novel and ideal animal model for high-throughput drug screening, to investigate the anti-inflammatory activities of 17 diterpene lactones isolated from AP.

Results: The results showed that most of diterpene lactones displayed significant anti-inflammatory effects in lipopolysaccharide microinjection-, copper sulfate exposure- or tail transection-induced zebrafish inflammation models.

Experimental study on seismic performance of a low-energy consumption composite wall structure of a pre-fabricated lightweight steel frame.

This study developed a low-energy consumption composite wall structure constructed with a pre-fabricated lightweight steel frame that is suitable for houses in villages and towns and evaluated its anti-seismic performance. A low-reversed cyclic-loading test was conducted on four full-scale pre-fabricated structure specimens, including a lightweight, concrete-filled steel tube (CFST) column frame specimen (abbreviated as SFCF), a lightweight CFST column frame composite wall specimen (abbreviated as SFCFW), an H-steel column frame specimen (abbreviated as HSCF) and an H-steel column frame composite wall specimen (abbreviated as HSCFW). The failure characteristics, hysteretic behaviour, strength, rigidity, ductility and energy dissipation capacity of each specimen were compared and analysed.