Urea Complexation for Docosahexaenoic Acid Enrichment from Crypthecodinium cohnii Oil: Using Water as the Urea Solvent.

Based on the observation that urea, water, and ethyl esters (EE) can form gypsum-like mixtures, this study explored the feasibility of employing water as a solvent for urea in the urea complexation method to enrich n-3 polyunsaturated fatty acids with docosahexaenoic acid (DHA)-containing ethyl esters (DHA- EE) from Crypthecodinium cohnii as the material. Under the conditions of a urea/DHA-EE ratio of 3, a water/DHA-EE ratio of 0.75, a mixing temperature of 65℃, and a cooling temperature of 20℃, a concentrate containing over 90% DHA was achieved.

Coordination-regulated copper single-atom active sites for electrochemical reduction of nitrate to ammonia.

The electrochemical conversion of nitrate to ammonia is necessary to restore the globally perturbed nitrogen cycle. Herein, the regulated coordination of active Cu single atoms to selectively modulate the energy barriers of proton-electron transfer steps was investigated and offered valuable insights for improving the selectivity and kinetics of the NORR.

Targeting glycolysis: exploring a new frontier in glioblastoma therapy.

Glioblastoma(GBM) is a highly malignant primary central nervous system tumor that poses a significant threat to patient survival due to its treatment resistance and rapid recurrence.Current treatment options, including maximal safe surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy, have limited efficacy.In recent years, the role of glycolytic metabolic reprogramming in GBM has garnered increasing attention.

Corrigendum: Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4 gain-of-function mutation.

[This corrects the article DOI: 10.3389/fimmu.2024.