Probing the Therapeutic Efficacy of Extract and GC-FID-Identified Phytochemicals as Novel Agents for Diabetes Mellitus.

Objectives: Oxidative stress is implicated in several metabolic cascades involved in glucose control. Hence, investigating antioxidant and antidiabetic activities is crucial for discovering an effective diabetes mellitus (DM) agent. This study was aimed at probing the therapeutic efficacy of hydro-ethanolic extract of (HECP) and gas chromatography-flame ionization detector (GC-FID)-identified phytochemicals as novel agents for DM.

Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients in a low-resource setting.

Introduction: diabetes mellitus can lead to complications including cardiovascular disease (CVD). Glycated haemoglobin (HbA1C) is a test of glycaemic control in T2DM patients, and its association with CVD can be mediated through modulation of risk factors such as dyslipidaemia. It is suggested that correlation of HbA1c with blood lipids may enable its use as a dual marker for glycaemic status and dyslipidaemia.

Potentiation Effects of Ficus sycomorus Active Fraction Against Permethrin-Resistant Field-Population of Anopheles coluzzii (Diptera: Culicidae).

Insecticide resistance in mosquitoes is increasing amidst growing cases of global malaria, leading to high fatality in mostly Africa. To overcome the resistance as well as environmental effects of the synthetic insecticides, preliminary insecticidal and botanical potentiating effects of sub-lethal concentration (LC) Ficus sycomorus active fraction (AFFS) and its synergistic potential with standard insecticide permethrin were evaluated against malarial vector Anopheles coluzzii (Coetzee & Wilkerson) populations. The glutathione-S-transferase (GST) inhibitory activity of the AFFS was also investigated compared to standard GST inhibitor, diethyl meleate (DEM).

Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients.

Background: There may be a possible link between the use of HAART and oxidative stress-related mitochondrial dysfunction in HIV patients. We evaluated the mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients attending the Enugu State University Teaching (ESUT) Hospital, Enugu, Nigeria following short and long-term therapy.

Methods: 96 patients categorized into four groups of 24 individuals were recruited for the study.

Alterations in the liver histology and markers of metabolic syndrome associated with inflammation and liver damage in L-arginine exposed female Wistar albino rats.

Metabolic Syndrome (MES), a cluster of metabolic disorders, is pandemic and more prevalent in females. It was associated with inflammation, liver damage and reduced nitric oxide concentration. Since L-arginine (ARG) may enhance nitric oxide synthesis, this study investigated the effect of ARG on the liver histology and selected serum markers of MES related to inflammation and liver damage.