Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.

Steroid-induced avascular necrosis of the femoral head (SANFH) is a progressive degenerative disease of the hip, primarily due to glucocorticoid (GC)-induced endothelial cell (EC) injury and compromised blood supply. Irisin is an EC-protective mytokine whose receptor is the integrin αVβ5. Caveolin-1 (CAV-1)， a major component of caveolae, causes endothelial dysfunction when phosphorylated.

Second harmonic and sum frequency generation in silicon nitride microring on thin-film lithium niobate.

We demonstrate significant second harmonic generation (SHG) and sum frequency generation (SFG) on a thin-film lithium niobate (TFLN) platform by loading a silicon nitride (SiN) microring resonator, which avoids the dry etching of lithium niobate. By optimizing SiN-loaded TFLN waveguide geometry, the phase-matching conditions between the fundamental pump laser and the SHG/SFG signals are designed. Combining with enhancement by the microring resonator, remarkable SHG and SFG signals with conversion efficiencies of 16.

Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures.

Background: Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer remains insufficiently investigated.

Methods: A total of 34 patients with a diagnosis of epithelial ovarian cancer (EOC), 15 patients with benign ovarian tumors (TB), and 30 healthy volunteers (NOR) were enrolled in this study.

Abdominal aortic aneurysm is a systemic and generalized arteriomegaly in mice and humans.

Although the pathogenesis of abdominal aortic aneurysm (AAA) remains largely unclear, evidence is accumulating to suggest the systemic nature of this disease. Here, we comprehensively assessed the whole aortic tree with its major branches based on computed tomography angiography (CTA) in AAA patients compared to ascending thoracic aortic aneurysm (ATAA) patients and nonaneurysmal controls, as well as in an original mouse model of AAA in Lkb1;Myh11-Cre/ERT2 mice. The morphology and dimensions of the whole aorta (at different levels) and its major branches were compared among 47 AAA patients, 47 ATAA patients, and 46 nonaneurysmal controls based on CTA images.

Construction and Application Research of a Perioperative Inspection Checklist for Acute Upper Gastrointestinal Bleeding.

Purpose: To enhance patient safety and improve communication and response times during the perioperative management of patients with acute upper gastrointestinal bleeding, a checklist was developed, tested for psychometric properties, and implemented in clinical practice.

Design: This is a methodological study.

Methods: A perioperative checklist for acute upper gastrointestinal bleeding was developed using a literature review and the Delphi method.