Fluocinolone Acetonide Enhances Anterograde Mitochondria Trafficking and Promotes Neuroprotection against Paclitaxel-Induced Peripheral Neuropathy.

Paclitaxel (PTX)-induced peripheral neuropathy (PIPN) is a debilitating health condition which is a result of degeneration of peripheral nerves found in extremities. Currently, there are no established treatment methods that can prevent or protect from PIPN. Fluocinolone acetonide (FA) has been recently identified as a potential candidate for protection from PIPN.

Long-term survival of the Lefèvre retentive cup: 12-year follow-up analysis of 466 consecutive cases.

Introduction: The Lefèvre retentive cup is a salvage solution for total hip replacement at high risk of dislocation. Only a few studies have reported the medium or long-term survival; most often, only a small number of patients were included in these studies. This led us to conduct a retrospective analysis of a large population to determine: 1) the 10-year survival rate after primary or revision arthroplasty, 2) the complication rate.

Hypoxia Occurrence in a Military Aviator Below 3048 m.

Introduction: Despite technological advances, hypoxia remains a concern in aviation. Hypoxia can present with a vast array of symptoms that are unique to each aviator. Military aviators undergo hypoxia awareness trainings to learn their unique constellation of hypoxia symptoms.

Midterm Survivorship of the Lefèvre Constrained Liner: A Consecutive Multisurgeon Series of 166 Cases.

Background: Constrained liners are used as part of a salvage procedure to provide stability for patients at high risk for dislocation after a total hip arthroplasty. However, no recent studies exist highlighting their effectiveness and/or limitations.

Method: This prospective review included 166 consecutive hip arthroplasties, either primary (27%) or revision (73%), with a unique design of a constrained liner: Lefèvre retentive cup.

Influence of experience on intra- and inter-observer reproducibility of the Crowe, Hartofilakidis and modified Cochin classifications.

Introduction: A previous study demonstrated that the reproducibility of the Crowe (Cr), the Hartofilakidis (Ha) and the modified Cochin (Co) classifications were comparable. However, there were differences with a trend that suggested the influence of experience. Therefore, we performed a prospective study to investigate whether experience influenced the reproducibility of the commonly used developmental dysplasia of the hip (DDH) classifications.