Publications by authors named "L Trapiellla-Martinez"
Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.
Semin Arthritis Rheum
October 2016
Objective: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc.
Methods: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE).
Article Synopsis
- Systemic sclerosis (SSc) is a rare disease with varying progression and prognosis, and this study analyzed survival rates and mortality causes in 879 Spanish patients.
- Among the patients, 15.7% died, with over half of those deaths attributed to SSc, primarily due to pulmonary hypertension.
- Key factors affecting survival included older age at disease onset, diffuse cutaneous SSc, interstitial lung disease, pulmonary hypertension, and scleroderma renal crisis, which were identified as independent risk factors for mortality.
Objective: To investigate the incidence of clinical and immunological characteristics of a large cohort of Spanish patients with scleroderma (SSc) and identifying factors associated with particular organ manifestations assessed by a nationwide cross-sectional analysis.
Methods: We classified SSc patients in 4 subsets using a modification of LeRoy and Medsger classification that included: "prescleroderma" (pre-SSc), limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc), and SSc sine scleroderma (ssSSc). Fourteen Spanish centers participated in patient recruitment.