Optimizing outcomes with maintenance IV UST in highly bio-exposed patients with IBD. Efficacy and adjusted regimen in real world.

Background And Aims: Ustekinumab is an effective treatment for inflammatory bowel diseases. However, some patients do not respond to conventional doses. The aim of the study was to evaluate the effectiveness of intravenous maintenance ustekinumab in patients with secondary failure.

Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications.

Introduction: MicroRNAs (miRNAs) are important epigenetic regulators in Crohn's disease (CD); however, their contribution to postoperative recurrence (POR) is still unknown. We aimed to characterize the potential role of miRNAs in predicting POR in patients with CD and to identify their pathogenic implications.

Methods: Of 67 consecutively operated patients with CD, we included 44 with pure ileal CD.

Ranking places in attributed temporal urban mobility networks.

Drawing on the recent advances in complex network theory, urban mobility flow patterns, typically encoded as origin-destination (OD) matrices, can be represented as weighted directed graphs, with nodes denoting city locations and weighted edges the number of trips between them. Such a graph can further be augmented by node attributes denoting the various socio-economic characteristics at a particular location in the city. In this paper, we study the spatio-temporal characteristics of "hotspots" of different types of socio-economic activities as characterized by recently developed attribute-augmented network centrality measures within the urban OD network.

Plasma Oncostatin M, TNF-α, IL-7, and IL-13 Network Predicts Crohn's Disease Response to Infliximab, as Assessed by Calprotectin Log Drop.

Background: Cytokines emerge as possible biomarkers of response in Crohn's disease (CD). We aimed to determine the plasmatic cytokine profiles of active CD patients who started infliximab (IFX) treatment and their capacity to predict the response to IFX.

Methods: A total of 30 active CD patients receiving an induction therapy of IFX were enrolled in the study.

Identification of Epigenetic Methylation Signatures With Clinical Value in Crohn's Disease.

Introduction: DNA methylation is an epigenetic mechanism that regulates gene expression and represents an important link between genotype, environment, and disease. It is a reversible and inheritable mechanism that could offer treatment targets. We aimed to assess the methylation changes on specific genes previously associated with Crohn's disease (CD) and to study their possible associations with the pathology.