Effect of systemic adenosine infusion on capillary flow and oxygen pressure distributions in skeletal muscle of the rabbit.

The aim of this study was to investigate the effect of systemic adenosine (ADO) infusion on blood flow and oxygenation at the capillary level in skeletal muscle in order to estimate oxygen demand. In anesthetized rabbits, a multiwire microelectrode was placed on the left vastus medialis muscle surface, and was used for capillary flow (determined by hydrogen clearance) as well as for oxygen pressure (PtO2) measurements. Laser Doppler flowmetry (LDF) was also used on the contralateral muscle surface for regional microcirculatory blood flow measurements.

Adenosine-induced increase in graft flow during coronary bypass surgery.

The influence of systemic adenosine infusion (30-50 micrograms/kg/min) on peroperative coronary graft flow was investigated in 16 patients undergoing bypass surgery. The central hemodynamic and graft flow (electromagnetic flow determination) responses were studied after 5-min, and in nine patients also after 30-min infusion. The low-dose adenosine infusion had little effect on the central hemodynamic parameters, while the graft flow increased in all patients (mean 84 +/- 12%, total 22 grafts).

Skeletal muscle oxygen pressure fields during controlled hypotension with adenosine and sodium nitroprusside. A comparative study in the rabbit.

The MDO (Mehrdraht Dortmund Oberfläche) multiwire oxygen electrode was used for studies of oxygen pressure fields in eight rabbit skeletal muscle preparations during controlled hypotension with adenosine and sodium nitroprusside (SNP). Tissue oxygen histograms were constructed from 120 simple tissue oxygen pressures (PtO2) samples that were collected during 5 min. Statistical analysis between histograms was performed with the two-sample Kolmogorov-Smirnov test.