Publications by authors named "L Tjoelker"
Article Synopsis
- Emerging cancers evolve to avoid immune detection by mutating key genes that help them present antigens, making them less visible to the immune system's Cytotoxic T lymphocytes.
- Cannabinoids, such as Δ9-tetrahydrocannabinol, cannabidiol, and cannabigerol, have been found to restore the expression of these MHC-I molecules on cancer cells, enhancing their recognition by the immune system.
- The research indicates that cannabinoids can modify epigenetic programs in metastatic tumors, which could aid in developing new cancer immunotherapy strategies by improving immune response against these tumors.
Mathematics is related to apheresis medicine. The safety of donor and patient in taking blood components is utterly important. Knowledge of total blood and plasma volume is needed and have to be calculated.
View Article and Find Full Text PDFThe COVID-19 pandemic had world wide an enormous impact on the complete global population and all daily activities. Not only in the work related situation, but also in the private. Fear to become infected, or infect third parties (family and other patients) is present, and in the same time organizing an apheresis unit country wide is a challenge.
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- The three complement activation pathways—classic pathway (CP), alternative pathway, and lectin pathway (LP)—all lead to the key event of C3 activation through formation of C3 convertases.
- The C3 convertase complex requires both components C4 and C2, which are essential for CP and LP activation; without C4, CP cannot activate C3.
- In the absence of C4 and/or C2, the LP can still activate C3 through the action of mannan-binding lectin-associated serine protease-2, demonstrating a bypass route for C3 activation in certain physiological conditions.
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We have established a platform for rapid discovery and optimization of mAbs ex vivo.
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