Publications by authors named "L Tizzoni"
Introduction: Disease recurrence after surgery is a crucial predictor of poor prognosis in colorectal cancer, where disseminated disease at the time of intervention can also be observed in localized early-stage cases. We evaluated the ability to predict disease recurrence of miRNAs from two signatures that we have found linked to the presence of colorectal cancer (CL signature) or adenoma (HgA signature) in higher-risk subjects.
Methods: miRNAs from the signatures were studied longitudinally by quantitative real-time polymerase chain reaction in plasma from 24 patients with resectable colorectal cancer collected at the time of surgery and during scheduled follow-up across 36 months.
Article Synopsis
- Li-Fraumeni syndrome (LFS) is a genetic disorder that increases the risk of developing various cancers, including brain tumors related to mutations in the TP53 gene.
- A study of medulloblastoma patients found that 12.5% had overexpressed the p53 protein, with two patients identified as carriers of TP53 mutations, one of whom had no notable family history.
- The research highlights the significance of genetic testing for TP53 mutations in patients with SHH-activated medulloblastoma, even if there is no family history of LFS, and reports the first documented case of a mosaic TP53 mutation in this context.
Colorectal cancer (CRC) screening programs help diagnose cancer precursors and early cancers and help reduce CRC mortality. However, currently recommended tests, the fecal immunochemical test (FIT) and colonoscopy, have low uptake. There is therefore a pressing need for screening strategies that are minimally invasive and consequently more acceptable to patients, most likely blood based, to increase early CRC identification.
View Article and Find Full Text PDFBackground: Classification of lung carcinoids into typical and atypical is a diagnostic challenge since no immunohistochemical tools are available to support pathologists in distinguishing between the two subtypes. A differential diagnosis is essential for clinicians to correctly discuss therapy, prognosis and follow-up with patients. Indeed, the distinction between the two typical and atypical subtypes on biopsies/cytological specimens is still unfeasible and sometimes limited also after radical surgeries.
View Article and Find Full Text PDFBackground: Early recognition of hypovolaemia in trauma patients is very important. However, the most often used clinical signs, such as hypotension and tachycardia, lack specificity and sensitivity.
Methods: We propose a non-invasive index of hypovolaemia, the heart to arm time (iHAT), based on a modified pulse transit time indexed to heart rate.