Publications by authors named "L Tiret"
In eukaryotic cells, the phospholipid cardiolipin (CL) is a crucial component that influences the function and organization of the mitochondrial inner membrane. In this study, we examined its potential role in passive proton transmembrane flux using unilamellar vesicles composed of natural egg phosphatidylcholine (PC) alone or with the inclusion of 18 or 34 mol % CL. A membrane potential was induced by a potassium gradient, and oxonol VI dye was used to monitor membrane potential dissipation resulting from proton transmembrane efflux.
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- Becker muscular dystrophy (BMD) is a less severe X-linked genetic disorder caused by mutations in the DMD gene, resulting in truncated dystrophin and affecting muscle function, particularly in the heart.
- Researchers created a rat model for BMD by deleting specific exons of the Dmd gene and evaluated the rats for functional and histopathological changes during their first year, finding moderate muscle damage and progressive heart disease.
- RNA sequencing of cardiac tissue revealed shared abnormalities in BMD and Duchenne muscular dystrophy (DMD) rats, pointing to issues with key proteins at cell junctions, which could help understand dystrophin's role in muscle and heart function, and pave the way for new treatments.
Fasting triglyceride concentrations are associated with markers of lipid metabolism and glucose homeostasis in healthy, non-obese dogs in lean and overweight condition.
Front Vet Sci
September 2024
Serum triglyceride concentrations increase in dogs with obesity, which is typically assessed by body condition score (BCS), however little is known about changes that take place in non-obese dogs in overweight condition. Further, the associations of triglyceride levels with other markers of energy homeostasis are poorly characterised in healthy animals. The present study aimed to evaluate associations between both BCS and triglyceride concentrations with other markers of lipid and glucose metabolism in healthy, non-obese dogs, as well as to assess whether these markers change significantly in non-obese dogs with overweight as compared to their lean counterparts.
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- - Duchenne muscular dystrophy (DMD) is a disease that causes muscles to weaken over time, making it hard for people to move and can also affect the heart and lungs.
- - Researchers studied the role of a protein called RIPK3, which is linked to muscle damage and inflammation, in both dogs and rats that have similar muscle problems as people with DMD.
- - The results showed that higher levels of RIPK3 were found in the damaged muscles and hearts of these animals, suggesting that RIPK3 might play a significant role in how DMD affects the heart and breathing.
Duchenne muscular dystrophy (DMD) is a severe and progressive myopathy leading to motor and cardiorespiratory impairment. We analyzed samples from patients with DMD and a preclinical rat model of severe DMD and determined that compromised repair capacity of muscle stem cells in DMD is associated with early and progressive muscle stem cell senescence. We also found that extraocular muscles (EOMs), which are spared by the disease in patients, contain muscle stem cells with long-lasting regenerative potential.
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