Publications by authors named "L Tiano"
An extensive body of literature has associated cancer with redox imbalance and inflammatory conditions. Thus, several studies and current clinical practice have relied on the use of anticancer drugs known to be associated with prooxidant state. On the other hand, a number of studies have reported on the effects of several antioxidants, anti-inflammatory agents and of mitochondrial cofactors (also termed mitochondrial nutrients, MNs) in counteracting or slowing carcinogenesis, or in controlling cancer growth.
View Article and Find Full Text PDFCoenzyme Q (CoQ) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...
View Article and Find Full Text PDFDevelopment and aging significantly impact the cellular levels of Coenzyme Q (CoQ), which is associated with both pathological and physiological conditions. Aim of this study was to describe the CoQ status throughout the lifetime of , a well-established model in aging studies. CoQ and CoQ distribution was analysed across different body segments and various life stages in both male and female flies.
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- Endothelial cellular senescence is linked to age-related vascular dysfunction, with changes in the glycocalyx and shedding of syndecan-4 (SDC4) noted in various age-related diseases.
- An in vitro study showed that inflammation and replicative senescence increased SDC4 expression and shedding in human endothelial cells, while analysis of plasma SDC4 levels in diabetic and healthy subjects revealed significant differences linked to cardiovascular events.
- High plasma levels of SDC4 in subjects with type 2 diabetes without complications were associated with lower risk of major adverse cardiovascular events (MACE), suggesting SDC4 could potentially serve as a prognostic marker for cardiovascular issues over time.
Article Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder linked to environmental factors like exposure to the neurotoxin rotenone, which disrupts mitochondrial function and harms dopaminergic neurons.
- The study aimed to explore how rotenone affects mitochondrial dysfunction and oxidative stress in SH-SY5Y neuronal cells and to see if Coenzyme Q (CoQ) could help reduce this stress.
- Findings showed that rotenone significantly inhibited mitochondrial enzyme activity and increased oxidative stress, but CoQ supplementation effectively lowered reactive oxygen species production and alleviated some of the neuronal damage.