Publications by authors named "L Teuwen"
Oncology is a rapidly evolving field globally, with a growing need to maintain research integrity. The African Organization for Research and Training in Cancer (AORTIC) has initiated a comprehensive training program to enhance research quality and integrity in African oncology. This program covers topics such as predatory publishing, data manipulation, plagiarism, “paper mills,” gender equity, and the critical appraisal of clinical trials and meta-analyses beyond statistical significance.
View Article and Find Full Text PDFPurpose: To evaluate safety, preliminary efficacy, pharmacokinetics, and pharmacodynamics, of fostroxacitabine bralpamide (fostrox, MIV-818), a novel oral troxacitabine nucleotide prodrug designed to direct exposure to the liver, while minimizing systemic toxicity.
Patients And Methods: Fostrox monotherapy was administered in an open-label, single-arm, first-in-human, phase 1a/1b study, in patients with hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, or solid tumor liver metastases. The first part (1a) consisted of intra/inter-patient escalating doses (3 mg to 70 mg) QD for up to 5 days, and the second part (1b), doses of 40 mg QD for 5 days, in 21-day cycles.
Article Synopsis
- The study examines disparities in location, gender, and funding among leadership roles in oncology clinical trials presented at the ASCO22 conference, highlighting the need for policies that promote diversity.
- Data from 239 phase III abstracts revealed a predominance of high-income country (HIC) institutions, with female representation as lead and senior authors at 29% and 23%, respectively.
- The findings indicate significant industry sponsorship, with 62% of trials funded by industry, and reflect an ongoing pattern of underrepresentation of women and low-income country authors in the field.
Time to update abstract submission categories to promote dissemination of global oncology research.
View Article and Find Full Text PDFPurpose: Conflicts of interest (COIs) between oncologists and industry might considerably influence how the presentation of the research results is delivered, ultimately affecting clinical decisions and policy-making. Although there are many regulations on reporting COI in high-income countries (HICs), little is known about their reporting in low- and middle-income countries (LMICs). Oncology Transparency Under Scrutiny and Tracking (ONCOTRUST-1) is a pilot global survey to explore the knowledge and perceptions of oncologists regarding COI.
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