Publications by authors named "L Tenorio"
Article Synopsis
- Autism spectrum disorder (ASD) is linked to mitochondrial dysfunction, which involves increased mitochondrial DNA (mtDNA) copy number and energy production issues; this study focused on key genes related to mtDNA replication to understand their role in ASD.
- Children with ASD showed higher mtDNA copy numbers and some mtDNA deletions in oral samples, but no significant changes were found in the expression of mitochondrial replisome genes compared to typically developing controls.
- Increased oxidative stress and inflammation were noted in ASD subjects, and while overexpressing the TFAM gene in cell cultures led to some mitochondrial benefits, this didn't directly tie to changes in gene expression or mtDNA integrity, indicating a complex relationship between mitochondrial dysfunction and ASD.
Introduction: Samples classified as indeterminate correspond to 10-20% of cytologies obtained by fine needle biopsy of thyroid nodules, preventing an adequate distinction between benign and malignant lesions and leading to diagnostic thyroidectomies that often prove unnecessary, as most cases are benign. Furthermore, although the vast majority of patients with differentiated thyroid cancer (DTC) have such a good prognosis that active surveillance is permitted as an initial therapeutic option, relapses are not rare, and a non-negligible number of patients experience poor outcomes. MicroRNAs (miR) emerge as potential biomarkers capable of helping to define more precise management of patients in all these situations.
View Article and Find Full Text PDFBackground: Thyroglossal duct cyst (TGDC) is the most common congenital neck mass among the pediatric population. Less than 10% of the cases occur in adults. The standard of care for TGDC is surgical treatment with the Sistrunk procedure via a traditional transverse cervicotomy.
View Article and Find Full Text PDFGrowing evidence demonstrates a continuous interaction between the immune system, the nerve and the muscle in neuromuscular disorders of different pathogenetic origins, such as Duchenne Muscular Dystrophy (DMD) and Amyotrophic Lateral Sclerosis (ALS), the focus of this review. Herein we highlight the complexity of the cellular and molecular interactions involving the immune system in neuromuscular disorders, as exemplified by DMD and ALS. We describe the distinct types of cell-mediated interactions, such as cytokine/chemokine production as well as cell-matrix and cell-cell interactions between T lymphocytes and other immune cells, which target cells of the muscular or nervous tissues.
View Article and Find Full Text PDFBackground: Areca nut and betel quid (ANBQ) chewing is a widespread carcinogenic habit. The BENIT (ClinicalTrials-NCT02942745) is the first known randomized trial designed for ANBQ chewers.
Methods: We compared the intensive behavioral treatment intervention condition (IC) with the control condition (CC) in the BENIT and included a 5-stage early stopping rule.