Publications by authors named "L Tartaglione"
In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability, allowing them to undergo considerable deformation when passing through the microcirculation. However, this deformability is compromised in Type 1 diabetes mellitus (T1DM) and related pathological conditions. This study aims to investigate the biomechanical properties of RBCs in T1DM patients, focusing on identifying significant mechanical alterations associated with microvascular complications (MCs).
View Article and Find Full Text PDFAims: This review evaluates the mechanisms underlying red blood cell (RBC) membrane fluidity changes in diabetes mellitus (DM) and explores strategies to assess and address these alterations. Emphasis is placed on developing a comprehensive index for membrane fluidity to improve monitoring and management in diabetic patients.
Materials And Methods: We reviewed current literature on RBC membrane fluidity, focussing on lipid composition, glycation, oxidative stress, and lipid transport alterations in diabetic patients.
Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?
J Headache Pain
October 2024
Article Synopsis
- Research indicates that patients with migraine with aura exhibit increased activity in visual cortices but struggle with adequate vascular supply during triggers, which may lead to aura symptoms.
- A study involving MRI assessed cerebral blood flow and connectivity in patients with migraine with and without aura, along with healthy controls.
- Results showed heightened blood flow in the visual cortex of migraine with aura patients, along with decreased neurovascular coupling, suggesting a misalignment between energy demand and supply in the brain.
Article Synopsis
- - Ostreopsis cf. ovata, a type of marine dinoflagellate, is spreading globally and causing harmful algal blooms (HABs) due to the production of toxic compounds known as ovatoxins, particularly OVTX-a.
- - The toxicity of these compounds remains unclear because there is a lack of high-purity reference materials for proper characterization and study.
- - Researchers have developed a refined isolation procedure for OVTX-a, leading to a notable increase in both yield and purity of the extracted toxin, which is essential for further research and understanding of its toxicity.
Variable outcomes have been reported with cefiderocol in infections due to carbapenem-resistant (CRAB). Nonetheless, it may be the only option for metallo-beta-lactamase-producing strains. We describe an outbreak of NDM-CRAB infections treated with cefiderocol.
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