Prognostic importance of biopsies and two-phase operations in the surgery of breast carcinoma (question of surgical dissemination of cancer cells).

The authors performed interval operations in 217 cases of breast carcinoma at the Department of Surgery of the National Cancer Institute, Budapest between 1950 and 1958. The number of 15-year survival followed up was 111 (51%). During the same period, after 667 one-phase operations the number of survivals followed up for 15 years was 184 (27.

[Results of the therapy of the carcinoma of the breast by partial mastectomy evaluation after over 15 years (author's transl)].

Between 1950 and 1960, 118 partial mastectomies in the treatment of early breast cancer have been carried out in four different techniques with block dissection and radiotherapy. The 5-10-15 year survivals were compared to a similar selection of 217 patients with radical operations. No significant differences could be found between the 5 and 10 years survival rates, but the number of patients living longer than 15 years is much higher following radical operation chiefly in the cases with stage II.

Some urgent problems in the treatment of operable breast cancer.

The results of 1216 radical mastectomies and 297 conservative surgical interventions performed on 1513 operable mammary carcinoma patients between 1950 and 1962 are analysed on the basis of the 10 years survival rate. It appears that early diagnosis and early operation will give the best result. The bioloical activity of the tumour is the most decisive additional factor.

Investigation of 17-ketosteriod excretion in mastopathia and premenopausal breast cancer.

Measurement of the excretion of total 17-ketosteroids, androsterone, etiocholanolone, and dehydroepiandrosterone demonstrate in contrast to the well known age dependency of normal women in cases of both mastopathia and breast cancer the following results: 1. the age dependence of the 17-ketosteriod excretion is not marked; 2. the total 17-ketosteroid excretion is lower than that of normal controls, 3.