Publications by authors named "L Talarico"
Due to their involvement in pathogen-mediated immune responses, the hypervariable genes of the Major Histocompatibility Complex (MHC) have become a paradigm for investigating the evolution and maintenance of genetic (adaptive) diversity, contextually providing insight into the viability of wild populations, which is meaningful for conservation. Here, we provide the first preliminary characterization of MHC polymorphism and evolution in trouts from Albania, a known hotspot of Salmonid diversity harboring ecologically and phylogenetically distinct native (threatened) taxa. Overall, 36 trout-including Lake Ohrid-endemic and , and both riverine and lacustrine native brown trout (the complex) from the Drin-Skadar drainage-were genotyped at the MHC- locus through next-generation amplicon sequencing.
View Article and Find Full Text PDFPolyvinyl alcohol (PVA), possessing a strong ability to form hydrogels, has been widely used for various pharmaceutical and biomedical applications. In particular, the use of PVA-PEG in the form of theta gels for altered cartilage treatment has attracted an enormous amount of attention in the last 20 years. In this paper, we prepared 42 PVA-PEG in the form of theta gels at room temperature in an aqueous environment, testing the crystallization occurrence at basic pH (10 or 12).
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- Dengue is a viral infection that can be mild or severe, and this study focused on pediatric cases during an outbreak in Buenos Aires from March to May 2023.
- A total of 112 patients were evaluated, mostly boys around 12 years old, with common symptoms including fever, headache, and muscle pain; leukopenia and elevated liver enzymes were the frequent lab findings.
- Early identification of clinical signs and lab results related to more severe cases is crucial for effective treatment, but no severe dengue cases were reported in this study.
Background: Humoral immune response against the pre-fusion (pre-F) conformation of respiratory syncytial virus (RSV) F protein has been proposed to play a protective role against infection. An RSV pre-F maternal vaccine has been recently approved in several countries to protect young infants against RSV. We aimed to assess serum IgG titers against the pre-F and post-F conformations of RSV F protein and their association with life-threatening RSV disease (LTD) in previously healthy infants.
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- Antibody-dependent enhancement (ADE) in dengue virus infection increases severity during secondary infections, with complement protein C1q shown to mitigate this effect in vitro.
- In experiments with human myeloid cell lines, C1q significantly reduced ADE of DENV-1 in K562 cells but had no impact on U937 cells, suggesting cell-type specificity in its action.
- C1q's modulation of ADE involved decreased viral adsorption and internalization, linked to different endocytic pathways and the expression of FcγR, highlighting the need for targeted drug and vaccine development strategies against dengue virus.