Publications by authors named "L Takser"
Background & Aims: Mood disorders and disorders of gut-brain interaction (DGBI) are highly prevalent, commonly comorbid, and lack fully effective therapies. Although selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for these disorders, they may impart adverse effects, including anxiety, anhedonia, dysmotility, and, in children exposed in utero, an increased risk of cognitive, mood, and gastrointestinal disorders. SSRIs act systemically to block the serotonin reuptake transporter and enhance serotonergic signaling in the brain, intestinal epithelium, and enteric neurons.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the impact of metal/element exposures on the gut microbiome in children aged 8 to 12, exploring the relationships between 19 different stool metal concentrations and microbiome profiles within a cohort of 116 participants from the GESTE study.
- - Significant associations were found, such as positive correlations between zinc (Zn) and certain microbiome species, while cadmium (Cd) was linked to declines in specific gut bacteria, indicating that metal exposure could affect the composition of the gut microbiome.
- - The research also identified 490 functional pathways related to microbiome activities, suggesting that these metal exposures could influence crucial processes like amino acid synthesis and carbohydrate degradation, highlighting the need for further research on their implications
Background: Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased probability of early cardiovascular disorders. Heterozygous familial hypercholesterolemia (HeFH) is the most common form, affecting approximately 1 in 250 individuals worldwide, with a higher prevalence among the French-Canadian population.
View Article and Find Full Text PDFArticle Synopsis
- * Specific HFRs like brominated diphenyl ethers (PBDEs) were measured in children from eastern Quebec, revealing that indoor environment conditions, such as air purifier usage, affect HFR levels in their bloodstream, with lower brominated compounds linked to better indoor quality.
- * Seasonal variations were observed, indicating higher levels of certain PBDEs in summer stool samples, while factors such as income and maternal education showed no significant influence on HFR exposure, although emerging compounds correlated with various
Article Synopsis
- A study measured 16 halogenated flame retardants in stool and plasma samples from children aged 8.9-13.8 years in a Canadian cohort, focusing on contaminants and their effects on neurodevelopment.
- The method used for stool analysis was effective, showing good recovery rates for most compounds, though some specific chemicals exhibited higher variability.
- The findings revealed significant differences in exposure patterns between stool and blood samples, suggesting that stool could be a valuable addition to blood analysis in future studies of chemical impacts on health, particularly regarding the gut microbiome.