Publications by authors named "L Taher"
Article Synopsis
- Transradial access (TRA) for mechanical thrombectomy in acute ischemic stroke is being considered as a safer alternative to the traditional transfemoral access (TFA), though its effectiveness is still being questioned.
- A meta-analysis examined 13 studies involving 4,759 patients and found no major difference in successful recanalization rates between TRA and TFA.
- However, when a specific study was excluded, the results suggested TFA might be more effective with better functional outcomes and a lower risk of needing to switch from TFA to TRA during procedures.
Article Synopsis
- Nodal marginal zone lymphoma (NMZL) is a rare subtype of non-Hodgkin lymphoma, making up about 2% of cases in both children and adults, often considered to be a mild disease but can be aggressive in adults.
- A 31-month-old boy with refractory EBV-positive NMZL experienced extensive disease that did not respond to initial chemotherapy or Rituximab, prompting treatment with second-line chemotherapy and an allogeneic hematopoietic stem cell transplant (HSCT).
- This case is significant as it is the first reported instance of a pediatric patient with refractory NMZL successfully treated with allogeneic stem cell transplant, indicating potential new treatment options for similar cases.
ENT3C: an entropy-based similarity measure for Hi-C and micro-C derived contact matrices.
NAR Genom Bioinform
September 2024
Hi-C and micro-C sequencing have shed light on the profound importance of 3D genome organization in cellular function by probing 3D contact frequencies across the linear genome. The resulting contact matrices are extremely sparse and susceptible to technical- and sequence-based biases, making their comparison challenging. The development of reliable, robust and efficient methods for quantifying similarity between contact matrices is crucial for investigating variations in the 3D genome organization in different cell types or under different conditions, as well as evaluating experimental reproducibility.
View Article and Find Full Text PDFObesity is predicted to affect approximately one-quarter of children/adolescents in Saudi Arabia by 2030, but there is limited evidence regarding the perceptions, attitudes, behaviours, and barriers to effective obesity care for adolescents living with obesity (ALwO), caregivers of ALwO, and healthcare professionals (HCPs). We report data from 500 ALwO (aged 12-<18 years), 500 caregivers, and 200 HCPs surveyed in Saudi Arabia as part of the global, cross-sectional ACTION Teens study (NCT05013359). Nearly all respondents recognized that obesity has a strong impact on overall health (ALwO 88%; caregivers 85%; HCPs 90%).
View Article and Find Full Text PDFBackground: Standard ChIP-seq and RNA-seq processing pipelines typically disregard sequencing reads whose origin is ambiguous ("multimappers"). This usual practice has potentially important consequences for the functional interpretation of the data: genomic elements belonging to clusters composed of highly similar members are left unexplored.
Results: In particular, disregarding multimappers leads to the underrepresentation in epigenetic studies of recently active transposable elements, such as AluYa5, L1HS and SVAs.