Publications by authors named "L T U H Melero"
Objective: To determine oncological outcomes and to identify prognostic factors in women aged <45 years with epithelial ovarian cancer.
Methods: A multicenter retrospective study was performed of patients treated for epithelial ovarian cancer aged <45 years between January 2010 and December 2019.
Results: A total of 998 patients with epithelial ovarian cancer from 55 different institutions in Spain were collected.
The Impact of Surgical Practice on Oncological Outcomes in Robot-Assisted Radical Hysterectomy for Early-Stage Cervical Cancer, Spanish National Registry.
Cancers (Basel)
January 2022
Article Synopsis
- * It compared two groups of hospitals, finding that those with higher recurrence rates (group B) had significant odds ratios indicating worse outcomes for recurrences, death, and disease-specific mortality.
- * Key factors linked to better outcomes included higher surgical volume, increased participation in clinical trials, more frequent MRI use, greater reliance on sentinel lymph node biopsies, and a positive learning curve with fewer early recurrences.
Aim: Bombesin (BBN) has demonstrated the ability to bind with high affinity and specificity to GRP receptor, overexpressed on human prostate cancer. A large number of BBN derivatives have been synthesized for this purpose but most of them exhibit high abdominal accumulation, which may represent a problem in their clinical use due to serious side effects to patients. In this study we describe the results of radiolabeling with lutetium-177, stability and in vivo studies of novel phenyl-glycine-extended bombesin derivatives.
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