Publications by authors named "L T Tsuneto"
Article Synopsis
- - The CYP2C19 gene is key for drug metabolism and exhibits high variability, influencing how drugs like escitalopram are processed in different populations, particularly in Native Americans.
- - Research shows that certain genetic variants (haplotypes) linked to CYP2C19 can cause discrepancies in expected drug metabolism rates, with a specific haplotype being more common in Native American groups than in other populations.
- - The study indicates that these genetic variations may explain differences between predicted metabolizing abilities and actual drug processing observed in Native American cohorts, highlighting the need for further research on this haplotype's effects.
Article Synopsis
- - Carbamazepine can cause skin hypersensitivity reactions linked to certain human leukocyte antigens (HLAs), and previous studies have identified specific genetic variants (rs1061235 and rs17179220) with predictive potential for these reactions in various populations.
- - The research examined how well these genetic variants serve as predictive markers in diverse groups of individuals with Native American ancestry, which are often overlooked in pharmacogenomic research.
- - The findings showed that while these variants performed well in some populations, they aren't consistently reliable across all Native American groups, indicating they may not be the best proxies for predicting adverse reactions to carbamazepine.
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells. KIR genes are encoded by a rapidly evolving gene family on chromosome 19 and present an unusual variation of presence and absence of genes and high allelic diversity. Although many studies have associated KIR polymorphism with susceptibility to several diseases over the last decades, the high-resolution allele-level haplotypes have only recently started to be described in populations.
View Article and Find Full Text PDFThe Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from 30 human populations, 28 of which are Native Americans, all of whom were typed for genomewide and MHC region microsatellites.
View Article and Find Full Text PDFThe American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a set of 424 Native American individuals.
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