Differences in immune response to Porphyromonas gingivalis.

About 341 (average age of 38.0 ± 2.5 years) patients with periodontal disease were included in this study.

[Osteoimmunnology and periodontitis].

Periodontal disease is a pathological condition that involves inflammation of the tooth supporting structures. Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. In this review, we discuss several aspects of the immune-inflammatory host response that ultimately results in loss of alveolar bone and stimulates osteoclastogenesis.

[Serine proteinase activity in children with hemolytic-uremic syndrome].

Haemolytic-uremic syndrome (HUS) is the leading cause of acute renal failure in the childhood. It is characterised by microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure and injury of the renal microvascular endothelium. In HUS the condition of proteolytic kallikrein-kinin system is unknown.

[Character of changes in indicators of proteinase and proteinase inhibitor activity in gastroenterological pathology in children].

The aim of this study was to determine trypsin-lake proteinase activity, chymotrypsin-like proteinase activity, trypsin, alpha 1-antitrypsin and alpha 2-macroglobulin levels in blood serum at the children with gastroenterological pathology. These parameters did not chang at the children with functional disorder of stomach and duodenum. The stable balance between proteinases and inhibitors was determined only at the duration of the disease not more 5 years.

[Hemolytic uremic syndrome as a clinical manifestation of oxidative stress].

An examination was made of seventeen children having various stages of the hemolytic uremic syndrome: Stage 1 is the period of an expanded clinical picture of the disease, the patients' condition is grave (anuria, azotemia, severe hemolytic anemia and thrombocytopenia); Stage 2 is the period of recovery. The plasma levels of malonic dialdehyde, dienic conjugates, alpha-tocopherol at the first stage of the disease were considerably higher than the control ones, on recovery there were their reductions though their levels remained higher than the normal levels. The levels of malonic dialdehyde in the red blood cell membranes in ill children were also much higher than those in healthy donors, but at the second stage they decreased, but remained high.