Publications by authors named "L T Lavras Costallat"
Article Synopsis
- A new consensus guideline by the Brazilian Society of Rheumatology was created to enhance the diagnosis and treatment of lupus nephritis (LN) through collaboration among 20 rheumatologists and methodologists, using systematic reviews and specific research questions.
- The guideline emphasizes essential testing for all systemic lupus erythematosus (SLE) patients, with kidney biopsy as the gold standard for LN diagnosis, and outlines 14 key recommendations including a defined target renal response (TRR) for monitoring treatment effectiveness.
- Hydroxychloroquine is recommended for all SLE patients unless contraindicated, and glucocorticoids are advised for managing LN based on effective grading strategies.
Objectives: The management of neuropsychiatric systemic lupus erythematosus (NPSLE) poses considerable challenges due to limited clinical trials. Therapeutic decisions are customized based on suspected pathogenic mechanisms and symptoms severity. This study aimed to investigate therapeutic strategies and disease outcome for patients with NPSLE experiencing their first neuropsychiatric (NP) manifestation.
View Article and Find Full Text PDFCentral nervous system (CNS) involvement in childhood-onset systemic lupus erythematosus (cSLE) occurs in more than 50% of patients. Structural magnetic resonance imaging (MRI) has identified global cerebral atrophy, as well as the involvement of the corpus callosum and hippocampus, which is associated with cognitive impairment. In this cross-sectional study we included 71 cSLE (mean age 24.
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